Article
Identification of MHC Ligands Through Allele-Guided Isolation Combined With Machine Learning for Improved MHC Assignment Using ARDisplay-I.
Molecular & cellular proteomics : MCP - 1 May 2026
Mecklenbräuker Shima, Skoczylas Piotr, Biernat Paweł, Zaghla Badeel Kh Q, Atay Bilge, Hossam Mai, Król-Józaga Bartłomiej, Jasiński Maciej, Pienkowski Victor Murcia, Sanecka-Duin Anna, Popp Oliver, Haji Mohamed, Szatanek Rafał, Mertins Philipp, Kaczmarczyk Jan, Keller Ulrich, Blum Agnieszka, Klatt Martin G
Abstract excerpt
The isolation of major histocompatibility complex (MHC) ligands and subsequent analysis by mass spectrometry is considered the gold standard for defining targets for T cell-based immunotherapies. However, as many targets of high tumor specificity are only presented at low abundance on the cell surface of tumor cells, the efficient isolation of these peptides is crucial for their successful detection. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.