Article

Structure modeling and specificity of peptide-MHC class I interactions using geometric deep learning

2022-12-19

Abstract excerpt

Major Histocompatibility Complex (MHC) plays a major role in the adaptive immune response by recognizing foreign proteins through binding to their peptides. In humans alone there are several hundred different MHC alleles, where each allele binds a specific subset of peptides. The peptide-MHC complex on a cell surface is identified by a T-cell receptor (TCR) and this binding invokes an immune response. Therefore, p...

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Literature Corpus work: fe3c8db4-aa27-5738-8769-efcc19cde9df
DOI: 10.1101/2022.12.15.520566

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