Article
A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer.
Genome medicine - 3 Apr 2023
Mayoh Chelsea, Gifford Andrew J, Terry Rachael, Lau Loretta M S, Wong Marie, Rao Padmashree, Shai-Hee Tyler, Saletta Federica, Khuong-Quang Dong-Anh, Qin Vicky, Mateos Marion K, Meyran Deborah, Miller Katherine E, Yuksel Aysen, Mould Emily V A, Bowen-James Rachel, Govender Dinisha, Senapati Akanksha, Zhukova Nataliya, Omer Natacha, Dholaria Hetal, Alvaro Frank, Tapp Heather, Diamond Yonatan, Pozza Luciano Dalla, Moore Andrew S, Nicholls Wayne, Gottardo Nicholas G, McCowage Geoffrey, Hansford Jordan R, Khaw Seong-Lin, Wood Paul J, Catchpoole Daniel, Cottrell Catherine E, Mardis Elaine R, Marshall Glenn M, Tyrrell Vanessa, Haber Michelle, Ziegler David S, Vittorio Orazio, Trapani Joseph A, Cowley Mark J, Neeson Paul J, Ekert Paul G
Abstract excerpt
BACKGROUND: Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a more refined appreciation of the TIME in childhood cancers, rather than a reliance on commonly used biomarkers such as tumour mutation burden (TMB), neoantigen load and PD-L1...
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