Article

The landscape of antigen-specific T cells in human cancers

2018-11-01

Abstract excerpt

Antigen-specific T cells can be orchestrated to kill cancer cells in immunotherapies but the utilities of the TCR information have not been fully explored. Here, we leveraged previous efforts on tumor TCR repertoire, and developed a novel algorithm to characterize antigen-specific TCR clusters. Joint analysis with gene expression revealed novel regulators for T cell activation. Investigation of single-cell sequenc...

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Literature Corpus work: 7198cea7-85a1-5596-aebc-575d36b184e9
DOI: 10.1101/459842

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