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Article

Investigation of Antigen-Specific T-Cell Receptor Clusters in Human Cancers

12 Dec 2019

Abstract excerpt

Abstract Purpose: Cancer antigen–specific T cells are key components in antitumor immune response, yet their identification in the tumor microenvironment remains challenging, as most cancer antigens are unknown. Recent advance in immunology suggests that similar T-cell receptor (TCR) sequences can be clustered to infer shared antigen specificity. This study aims to identify antigen-specific TCRs from the tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31831563
DOI: 10.1158/1078-0432.ccr-19-3249

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