Article
Genomic and Transcriptomic Analysis of Relapsed and Refractory Childhood Solid Tumors Reveals a Diverse Molecular Landscape and Mechanisms of Immune Evasion.
Cancer research - 1 Dec 2021
Byron Sara A, Hendricks William P D, Nagulapally Abhinav B, Kraveka Jacqueline M, Ferguson William S, Brown Valerie I, Eslin Don E, Mitchell Deanna, Cornelius Albert, Roberts William, Isakoff Michael S, Oesterheld Javier E, Wada Randal K, Rawwas Jawhar, Neville Kathleen, Zage Peter E, Harrod Virginia L, Bergendahl Genevieve, VanSickle Elizabeth, Dykema Karl, Bond Jeffrey, Chou Hsien-Chao, Wei Jun S, Wen Xinyu, Reardon Hue V, Roos Alison, Nasser Sara, Izatt Tyler, Enriquez Daniel, Hegde Apurva M, Cisneros Faith, Christofferson Austin, Turner Bryce, Szelinger Szabolcs, Keats Jonathan J, Halperin Rebecca F, Khan Javed, Saulnier Sholler Giselle L, Trent Jeffrey M
Abstract excerpt
Children with treatment-refractory or relapsed (R/R) tumors face poor prognoses. As the genomic underpinnings driving R/R disease are not well defined, we describe here the genomic and transcriptomic landscapes of R/R solid tumors from 202 patients enrolled in Beat Childhood Cancer Consortium clinical trials. Tumor mutational burden (TMB) was elevated relative to untreated tumors at diagnosis, with one-third of...
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