The neuronal transporter gene SLC6A15 confers risk to major depression.

doi:10.1016/j.neuron.2011.04.005

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The neuronal transporter gene SLC6A15 confers risk to major depression.

Neuron - 28 Apr 2011

Kohli Martin A, Lucae Susanne, Saemann Philipp G, Schmidt Mathias V, Demirkan Ayse, Hek Karin, Czamara Darina, Alexander Michael, Salyakina Daria, Ripke Stephan, Hoehn David, Specht Michael, Menke Andreas, Hennings Johannes, Heck Angela, Wolf Christiane, Ising Marcus, Schreiber Stefan, Czisch Michael, Müller Marianne B, Uhr Manfred, Bettecken Thomas, Becker Albert, Schramm Johannes, Rietschel Marcella, Maier Wolfgang, Bradley Bekh, Ressler Kerry J, Nöthen Markus M, Cichon Sven, Craig Ian W, Breen Gerome, Lewis Cathryn M, Hofman Albert, Tiemeier Henning, van Duijn Cornelia M, Holsboer Florian, Müller-Myhsok Bertram, Binder Elisabeth B

Abstract excerpt

Major depression (MD) is one of the most prevalent psychiatric disorders and a leading cause of loss in work productivity. A combination of genetic and environmental risk factors probably contributes to MD. We present data from a genome-wide association study revealing a neuron-specific neutral amino acid transporter (SLC6A15) as a susceptibility gene for MD. Risk allele carrier status in humans and chronic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Transport Systems, Neutral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aspartic Acid

Share to Chromosomes, Human, Pair 12

Share to Depressive Disorder, Major

Share to Magnetic Resonance Spectroscopy

Share to Meta-Analysis as Topic

Share to Stress, Psychological

Share to Tritium

Source

Open in PubMed Open full text

Identifiers

PMID: 21521612
DOI: 10.1016/j.neuron.2011.04.005
PMCID: PMC3112053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The neuronal transporter gene SLC6A15 confers risk to major depression.PMID 21521612Read ↗

Functional coding variants in SLC6A15, a possible risk gene for major depression.Semantic proximity Read ↗

SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system.Semantic proximity Read ↗

Effects of a Polymorphism of the Neuronal Amino Acid Transporter SLC6A15 Gene on Structural Integrity of White Matter Tracts in Major Depressive Disorder.Semantic proximity Read ↗

Identification of SLC25A37 as a major depressive disorder risk gene.Semantic proximity Read ↗

Whole exome sequencing in the UK Biobank reveals risk gene<i>SLC2A1</i>and biological insights for major depressive disorderSemantic proximity Read ↗

Genetics of serotonin receptors and depression: state of the art.Semantic proximity Read ↗

A Combined Study of SLC6A15 Gene Polymorphism and the Resting-State Functional Magnetic Resonance Imaging in First-Episode Drug-Naive Major Depressive Disorder.Semantic proximity Read ↗

The association between polymorphism of norepinephrine transporter G1287A and major depressive disorder, antidepressant response: a meta-analysis.Semantic proximity Read ↗

5HTTLPR Genetic Variant and Major Depressive Disorder: A Review.Semantic proximity Read ↗

Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes.Semantic proximity Read ↗

Association Study of the SLC1A2 (rs4354668), SLC6A9 (rs2486001) and SLC6A5 (rs2000959) Polymorphisms in Major Depressive DisorderSemantic proximity Read ↗

Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.