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Article

SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system.

Stress (Amsterdam, Netherlands) - 1 Jan 2016

Santarelli S, Wagner K V, Labermaier C, Uribe A, Dournes C, Balsevich G, Hartmann J, Masana M, Holsboer F, Chen A, Müller M B, Schmidt M V

Abstract excerpt

Major depression is a multifactorial disease, involving both environmental and genetic risk factors. Recently, SLC6A15 - a neutral amino acid transporter mainly expressed in neurons - was proposed as a new candidate gene for major depression and stress vulnerability. Risk allele carriers for a single nucleotide polymorphism (SNP) in a SLC6A15 regulatory region display altered hippocampal volume, glutamate levels,...

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Identifiers

PMID: 26585320
DOI: 10.3109/10253890.2015.1105211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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