Article
Ablation of Type III Adenylyl Cyclase in Mice Causes Reduced Neuronal Activity, Altered Sleep Pattern, and Depression-like Phenotypes.
Biological psychiatry - 1 Dec 2016
Chen Xuanmao, Luo Jie, Leng Yihua, Yang Yimei, Zweifel Larry S, Palmiter Richard D, Storm Daniel R
Abstract excerpt
BACKGROUND: Although major depressive disorder (MDD) has low heritability, a genome-wide association study in humans has recently implicated type 3 adenylyl cyclase (AC3; ADCY3) in MDD. Moreover, the expression level of AC3 in blood has been considered as a MDD biomarker in humans. Nevertheless, there is a lack of supporting evidence from animal studies. METHODS: We employed multiple approaches to experimentally...
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