Article

NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA

2023-05-09

Abstract excerpt

<title>Abstract</title> <p>Major depressive disorder (MDD) is characterized by diverse debilitating symptoms that include loss of motivation and anhedonia. If multiple medications, psychotherapy, and electroconvulsive therapy fail in some patients with MDD, their condition is then termed treatment–resistant depression (TRD). MDD can be associated with abnormalities in the reward–system–dopaminergic mesolimbic pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f8611366-20af-5a6c-be92-83dddbd6f353
DOI: 10.21203/rs.3.rs-2869497/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTADOI 10.21203/rs.3.rs-2869497/v1Read

NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTASemantic proximity Read

Dopamine neurons modulate neural encoding and expression of depression-related behaviour.Semantic proximity Read

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons.Semantic proximity Read

Ketamine rescues anhedonia by cell-type and input specific adaptations in the Nucleus AccumbensSemantic proximity Read

Ventral tegmental area dopaminergic lesion-induced depressive phenotype in the rat is reversed by deep brain stimulation of the medial forebrain bundle.Semantic proximity Read

Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenulaSemantic proximity Read

Convergence of clinically relevant manipulations on dopamine-regulated prefrontal activity underlying stress-coping responsesSemantic proximity Read

Deficit of neuronal EAAT2 impairs hippocampus CA3 neuron's activity and may induce depressive like behaviors.Semantic proximity Read

Dysregulation of brain dopamine systems in major depressive disorderSemantic proximity Read

A Clinically Aligned Murine Model of Electroconvulsive Stimulation Reverses Social Aversion and Displays Fear Memory Impairment After Chronic Social Defeat StressSemantic proximity Read

Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice.Semantic proximity Read

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors.Semantic proximity Read