Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders.

doi:10.1038/s41467-025-57760-3

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Article

Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders.

Nature communications - 14 Mar 2025

Cilleros-Portet Ariadna, Lesseur Corina, Marí Sergi, Cosin-Tomas Marta, Lozano Manuel, Irizar Amaia, Burt Amber, García-Santisteban Iraia, Garrido-Martín Diego, Escaramís Geòrgia, Hernangomez-Laderas Alba, Soler-Blasco Raquel, Breeze Charles E, Gonzalez-Garcia Bárbara P, Santa-Marina Loreto, Chen Jia, Llop Sabrina, Fernández Mariana F, Vrijheid Martine, Ibarluzea Jesús, Guxens Mònica, Marsit Carmen, Bustamante Mariona, Bilbao Jose Ramon, Fernandez-Jimenez Nora

Abstract excerpt

Increasing evidence supports the role of the placenta in neurodevelopment and in the onset of neuropsychiatric disorders. Recently, mQTL and iQTL maps have proven useful in understanding relationships between SNPs and GWAS that are not captured by eQTL. In this context, we propose that part of the genetic predisposition to complex neuropsychiatric disorders acts through placental DNA methylation. We construct a...

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PMID: 40087310
DOI: 10.1038/s41467-025-57760-3
PMCID: PMC11909199

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