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Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders

12 Nov 2018

Abstract excerpt

BACKGROUND: Genetic influences on gene expression in the human fetal brain plausibly impact upon a variety of postnatal brain-related traits, including susceptibility to neuropsychiatric disorders. However, to date, there have been no studies that have mapped genome-wide expression quantitative trait loci (eQTL) specifically in the human prenatal brain. RESULTS: We performed deep RNA sequencing and genome-wide...

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Share to Fetal and Pediatric Neurological Disorders
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Share to Genomic variations and chromosomal abnormalities

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PMID: 30419947
DOI: 10.1186/s13059-018-1567-1

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