Article

Integrating brain methylome with GWAS for psychiatric risk gene discovery

2018-10-11

Abstract excerpt

DNA methylation (DNAm) is heritable and plays a role in brain development and function through transcriptional regulation. Aberrant DNAm in human brain has been linked to psychiatric disorders, potentially as mediators of common genetic risk variants. In this study, we hypothesize that common risk variants for psychiatric disorders may act through affecting DNAm level in human brain. We first aimed to investigate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5bf1159-48ff-5f89-90a9-a93b687fa7e0
DOI: 10.1101/440206

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrating brain methylome with GWAS for psychiatric risk gene discoveryDOI 10.1101/440206Read

Widespread methylation quantitative trait loci and their role in schizophrenia riskSemantic proximity Read

Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk.Semantic proximity Read

Association of a Reproducible Epigenetic Risk Profile for Schizophrenia With Brain Methylation and FunctionSemantic proximity Read

Patterns of methylation heritability in a genome-wide analysis of four brain regions.Semantic proximity Read

Identification of genetic variants influencing methylation in brain with pleiotropic effects on psychiatric disorders.Semantic proximity Read

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex.Semantic proximity Read

A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue.Semantic proximity Read

Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study.Semantic proximity Read

Genome-wide methylome analyses reveal novel epigenetic regulation patterns in schizophrenia and bipolar disorder.Semantic proximity Read

Epigenetics in Schizophrenia: A Pilot Study of Global DNA Methylation in Different Brain Regions Associated with Higher Cognitive FunctionsSemantic proximity Read

Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders.Semantic proximity Read

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.Semantic proximity Read