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Article

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex.

Nature neuroscience - 1 Jan 2016

Jaffe Andrew E, Gao Yuan, Deep-Soboslay Amy, Tao Ran, Hyde Thomas M, Weinberger Daniel R, Kleinman Joel E

Abstract excerpt

DNA methylation (DNAm) is important in brain development and is potentially important in schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric controls across the lifespan and 191 patients with schizophrenia and identified widespread changes in the transition from prenatal to postnatal life. These DNAm changes manifest in the transcriptome, correlate strongly with a shifting cellular...

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Identifiers

PMID: 26619358
DOI: 10.1038/nn.4181
PMCID: PMC4783176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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