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Article

Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk.

Nature communications - 2 Sept 2021

Perzel Mandell Kira A, Eagles Nicholas J, Wilton Richard, Price Amanda J, Semick Stephen A, Collado-Torres Leonardo, Ulrich William S, Tao Ran, Han Shizhong, Szalay Alexander S, Hyde Thomas M, Kleinman Joel E, Weinberger Daniel R, Jaffe Andrew E

Abstract excerpt

DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed DNAm in 344 samples of human postmortem brain tissue from neurotypical subjects and individuals with schizophrenia. We identify genetic influence on local methylation levels throughout the genome, both at CpG sites and CpH sites, with 86% of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34475392
DOI: 10.1038/s41467-021-25517-3
PMCID: PMC8413445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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