Article

Placental DNA methylation captures shared and trait-specific genetic susceptibility across complex health conditions

2026-07-09

Abstract excerpt

The Developmental Origins of Health and Disease (DOHaD) hypothesis proposes that the perinatal environment shapes susceptibility to complex traits across life [1]. The placenta, a transient organ mediating maternal-fetal exchange, plays a central role in this process and has emerged as a key molecular archive in utero [2–4]. Placental DNA methylation (DNAm) is a unique mediator between prenatal exposures, fetal g...

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Literature Corpus work: 5c15c5db-cb5d-5a3c-9600-23cf9b27f584
DOI: 10.64898/2026.07.07.26357471

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