Article

Placental gene expression mediates the interaction between obstetrical history and genetic risk for schizophrenia

2017-06-07

Abstract excerpt

Defining the environmental context in which genes enhance susceptibility can provide insight into the pathogenesis of complex disorders, like schizophrenia. Here we show that the intrauterine and perinatal environment modulates the association of schizophrenia with genomic risk, as measured with polygenic risk scores (PRS) based primarily on GWAS significant variants. Genomic risk interacts with intrauterine and p...

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Literature Corpus work: e156e8ff-bcb8-5790-974c-56c70f829e47
DOI: 10.1101/147207

Open publication

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