Article
Convergence of placenta biology and genetic risk for schizophrenia.
Nature medicine - 1 Jun 2018
Ursini Gianluca, Punzi Giovanna, Chen Qiang, Marenco Stefano, Robinson Joshua F, Porcelli Annamaria, Hamilton Emily G, Mitjans Marina, Maddalena Giancarlo, Begemann Martin, Seidel Jan, Yanamori Hidenaga, Jaffe Andrew E, Berman Karen F, Egan Michael F, Straub Richard E, Colantuoni Carlo, Blasi Giuseppe, Hashimoto Ryota, Rujescu Dan, Ehrenreich Hannelore, Bertolino Alessandro, Weinberger Daniel R
Abstract excerpt
Defining the environmental context in which genes enhance disease susceptibility can provide insight into the pathogenesis of complex disorders. We report that the intra-uterine environment modulates the association of schizophrenia with genomic risk (in this study, genome-wide association study-derived polygenic risk scores (PRSs)). In independent samples from the United States, Italy, and Germany, the liability...
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