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Article

Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci.

Nature neuroscience - 1 Jan 2016

Hannon Eilis, Spiers Helen, Viana Joana, Pidsley Ruth, Burrage Joe, Murphy Therese M, Troakes Claire, Turecki Gustavo, O'Donovan Michael C, Schalkwyk Leonard C, Bray Nicholas J, Mill Jonathan

Abstract excerpt

We characterized DNA methylation quantitative trait loci (mQTLs) in a large collection (n = 166) of human fetal brain samples spanning 56-166 d post-conception, identifying >16,000 fetal brain mQTLs. Fetal brain mQTLs were primarily cis-acting, enriched in regulatory chromatin domains and transcription factor binding sites, and showed substantial overlap with genetic variants that were also associated with gene...

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Identifiers

PMID: 26619357
DOI: 10.1038/nn.4182
PMCID: PMC4714325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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