Article
Placental genomic risk scores and early neurodevelopmental outcomes.
Proceedings of the National Academy of Sciences of the United States of America - 16 Feb 2021
Ursini Gianluca, Punzi Giovanna, Langworthy Benjamin W, Chen Qiang, Xia Kai, Cornea Emil A, Goldman Barbara D, Styner Martin A, Knickmeyer Rebecca C, Gilmore John H, Weinberger Daniel R
Abstract excerpt
Tracing the early paths leading to developmental disorders is critical for prevention. In previous work, we detected an interaction between genomic risk scores for schizophrenia (GRSs) and early-life complications (ELCs), so that the liability of the disorder explained by genomic risk was higher in the presence of a history of ELCs, compared with its absence. This interaction was specifically driven by loci...
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