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Smoking behavior-related genetic variants and lung cancer risk in Japanese: an assessment by mediation analysis.

Carcinogenesis - 3 Apr 2025

Yamamoto Sayaka, Koyanagi Yuriko N, Iwashita Yuji, Shinozaki Tomohiro, Fujiwara Yutaka, Sakakura Noriaki, Hara Megumi, Nishida Yuichiro, Otonari Jun, Ikezaki Hiroaki, Tanoue Shiroh, Koriyama Chihaya, Kasugai Yumiko, Oze Isao, Koyama Teruhide, Tomida Satomi, Michihata Nobuaki, Nakamura Yohko, Suzuki Sadao, Nakagawa-Senda Hiroko, Nagayoshi Mako, Kubo Yoko, Kato Yasufumi, Wakai Kenji, Watanabe Takeshi, Ishizu Masashi, Takashima Naoyuki, Kadota Aya, Momozawa Yukihide, Nakatochi Masahiro, Tamura Takashi, Niimi Akio, Ito Hidemi, Matsuo Keitaro

Abstract excerpt

Cigarette smoking is one of the most important risk factors for lung cancer. Genetic studies have shown that smoking behavior-related genetic variants are directly associated with lung cancer, independent of smoking behavior, mainly in European populations. A recent genome-wide association study in Japan identified five loci associated with the number of cigarettes smoked per day. This study aimed to evaluate...

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PMID: 40059777
DOI: 10.1093/carcin/bgaf011

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CLU
CYP2A6
EPHX2

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