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Article

From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes.

BMC cancer - 14 Sept 2020

Chen Zhishan, Wen Wanqing, Cai Qiuyin, Long Jirong, Wang Ying, Lin Weiqiang, Shu Xiao-Ou, Zheng Wei, Guo Xingyi

Abstract excerpt

BACKGROUND: Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutational signature. METHODS: We systematically analyzed the smoking-related DNA methylation sites reported from five previous casecontrol studies in peripheral blood cells to identify possible target...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32928150
DOI: 10.1186/s12885-020-07368-1
PMCID: PMC7488848

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