Article
A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Aug 2022
Zhang Ruyang, Shen Sipeng, Wei Yongyue, Zhu Ying, Li Yi, Chen Jiajin, Guan Jinxing, Pan Zoucheng, Wang Yuzhuo, Zhu Meng, Xie Junxing, Xiao Xiangjun, Zhu Dakai, Li Yafang, Albanes Demetrios, Landi Maria Teresa, Caporaso Neil E, Lam Stephen, Tardon Adonina, Chen Chu, Bojesen Stig E, Johansson Mattias, Risch Angela, Bickeböller Heike, Wichmann H-Erich, Rennert Gadi, Arnold Susanne, Brennan Paul, McKay James D, Field John K, Shete Sanjay S, Le Marchand Loic, Liu Geoffrey, Andrew Angeline S, Kiemeney Lambertus A, Zienolddiny-Narui Shan, Behndig Annelie, Johansson Mikael, Cox Angela, Lazarus Philip, Schabath Matthew B, Aldrich Melinda C, Dai Juncheng, Ma Hongxia, Zhao Yang, Hu Zhibin, Hung Rayjean J, Amos Christopher I, Shen Hongbing, Chen Feng, Christiani David C
Abstract excerpt
INTRODUCTION: Although genome-wide association studies have been conducted to investigate genetic variation of lung tumorigenesis, little is known about gene-gene (G × G) interactions that may influence the risk of non-small cell lung cancer (NSCLC). METHODS: Leveraging a total of 445,221 European-descent participants from the International Lung Cancer Consortium OncoArray project, Transdisciplinary Research in...
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