Article
A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.
Carcinogenesis - 1 Jul 2014
Zhang Ruyang, Chu Minjie, Zhao Yang, Wu Chen, Guo Huan, Shi Yongyong, Dai Juncheng, Wei Yongyue, Jin Guangfu, Ma Hongxia, Dong Jing, Yi Honggang, Bai Jianling, Gong Jianhang, Sun Chongqi, Zhu Meng, Wu Tangchun, Hu Zhibin, Lin Dongxin, Shen Hongbing, Chen Feng
Abstract excerpt
Tobacco smoke is the major environmental risk factor underlying lung carcinogenesis. However, approximately one-tenth smokers develop lung cancer in their lifetime indicating there is significant individual variation in susceptibility to lung cancer. And, the reasons for this are largely unknown. In particular, the genetic variants discovered in genome-wide association studies (GWAS) account for only a small...
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