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Article

Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction.

American journal of epidemiology - 15 May 2012

VanderWeele Tyler J, Asomaning Kofi, Tchetgen Tchetgen Eric J, Han Younghun, Spitz Margaret R, Shete Sanjay, Wu Xifeng, Gaborieau Valerie, Wang Ying, McLaughlin John, Hung Rayjean J, Brennan Paul, Amos Christopher I, Christiani David C, Lin Xihong

Abstract excerpt

Genome-wide association studies have identified variants on chromosome 15q25.1 that increase the risks of both lung cancer and nicotine dependence and associated smoking behavior. However, there remains debate as to whether the association with lung cancer is direct or is mediated by pathways related to smoking behavior. Here, the authors apply a novel method for mediation analysis, allowing for gene-environment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22306564
DOI: 10.1093/aje/kwr467
PMCID: PMC3353137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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