Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma.

PloS one - 1 Jan 2014

Tseng Tung-Sung, Park Jong Y, Zabaleta Jovanny, Moody-Thomas Sarah, Sothern Melinda S, Chen Ted, Evans David E, Lin Hui-Yi

Abstract excerpt

Several variations in the nicotinic receptor genes have been identified to be associated with both lung cancer risk and smoking in the genome-wide association (GWA) studies. However, the relationships among these three factors (genetic variants, nicotine dependence, and lung cancer) remain unclear. In an attempt to elucidate these relationships, we applied mediation analysis to quantify the impact of nicotine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Lung Neoplasms

Share to Receptors, Nicotinic

Share to Risk Factors

Share to Smoking

Share to Tobacco Use Disorder

Source

Open in PubMed Open full text

Identifiers

PMID: 25233467
DOI: 10.1371/journal.pone.0107268
PMCID: PMC4169410

Genes

CHRNA5
CHRNA3
TERT
CHRNA6
CHRNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma.PMID 25233467Read ↗

Smoking behavior-related genetic variants and lung cancer risk in Japanese: an assessment by mediation analysis.Semantic proximity Read ↗

From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes.Semantic proximity Read ↗

Nicotinic acetylcholine receptors and predisposition to lung cancer.Semantic proximity Read ↗

Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.Semantic proximity Read ↗

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.Semantic proximity Read ↗

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.Semantic proximity Read ↗

Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population.Semantic proximity Read ↗

Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.Semantic proximity Read ↗

Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population.Semantic proximity Read ↗

Nicotine dependence and genetic variation in the nicotinic receptors.Semantic proximity Read ↗

The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer.Semantic proximity Read ↗

Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.