Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk.

PloS one - 1 Jan 2012

Wang Jian, Spitz Margaret R, Amos Christopher I, Wu Xifeng, Wetter David W, Cinciripini Paul M, Shete Sanjay

Abstract excerpt

A mediation model explores the direct and indirect effects between an independent variable and a dependent variable by including other variables (or mediators). Mediation analysis has recently been used to dissect the direct and indirect effects of genetic variants on complex diseases using case-control studies. However, bias could arise in the estimations of the genetic variant-mediator association because the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Models, Theoretical

Share to Nerve Tissue Proteins

Share to Pulmonary Disease, Chronic Obstructive

Share to Receptors, Nicotinic

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 23077662
DOI: 10.1371/journal.pone.0047705
PMCID: PMC3471886

Genes

CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk.PMID 23077662Read ↗

Efficient Estimation of Indirect Effects in Case-Control Studies Using a Unified Likelihood FrameworkSemantic proximity Read ↗

Examining the role of unmeasured confounding in mediation analysis with genetic and genomic applicationsSemantic proximity Read ↗

Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk.Semantic proximity Read ↗

Smoking behavior-related genetic variants and lung cancer risk in Japanese: an assessment by mediation analysis.Semantic proximity Read ↗

Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility.Semantic proximity Read ↗

High-dimensional causal mediation analysis by partial sum statistic and sample splitting strategy in imaging genetics applicationSemantic proximity Read ↗

Large-Scale Hypothesis Testing for Causal Mediation Effects with Applications in Genome-wide Epigenetic StudiesSemantic proximity Read ↗

A mediation analysis framework based on variance component to remove genetic confounding effect.Semantic proximity Read ↗

A multiple mediator analysis approach to quantify the effects of the ADH1B and ALDH2 genes on hepatocellular carcinoma risk.Semantic proximity Read ↗

Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction.Semantic proximity Read ↗

MASH: Mediation Analysis of Survival Outcome and High-dimensional Omics Mediators with Application to Complex DiseasesSemantic proximity Read ↗

Integrative modeling of multi-platform genomic data under the framework of mediation analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.