Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insights into the transcriptional regulation of CD22 in B cell chronic lymphocytic leukemia

5 Mar 2025

Abstract excerpt

CD22 (also known as Siglec-2) is a member of the Siglec family of glycan-recognition proteins and functions as a negative regulator of the B-cell receptor-mediated calcium signaling. Although the low level of CD22 expression on the B cells in patients with chronic lymphocytic leukemia (CLL) has been documented, CD22's role and its downregulation mechanism in CLL are yet to be fully studied. In this study, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Glycosylation and Glycoproteins Research
Share to Lymphoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40054694
DOI: 10.1016/j.jbc.2025.108386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insights into the transcriptional regulation of CD22 in B cell chronic lymphocytic leukemiaPMID 40054694Read ↗

CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1.Semantic proximity Read ↗

CD20: a gene in search of a function.Semantic proximity Read ↗

A transcription factor PU.1 is critical for Ccl22 gene expression in dendritic cells and macrophagesSemantic proximity Read ↗

Identification of a gene on chromosome 12q22 uniquely overexpressed in chronic lymphocytic leukemia.Semantic proximity Read ↗

CD22 and Autoimmune DiseaseSemantic proximity Read ↗

CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemiaSemantic proximity Read ↗

CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo.Semantic proximity Read ↗

Screening of Variations in CD22 Gene in Children with B-Precursor Acute Lymphoblastic Leukemia.Semantic proximity Read ↗

Identification of the gene variations in human CD22.Semantic proximity Read ↗

Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemiaSemantic proximity Read ↗

Internalization of the lymphocytic surface protein CD22 is controlled by a novel membrane proximal cytoplasmic motif.Semantic proximity Read ↗

B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.