Article
CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2006
Haas Karen M, Sen Suman, Sanford Isaac G, Miller Ann S, Poe Jonathan C, Tedder Thomas F
Abstract excerpt
The CD22 extracellular domain regulates B lymphocyte function by interacting with alpha2,6-linked sialic acid-bearing ligands. To understand how CD22 ligand interactions affect B cell function in vivo, mouse anti-mouse CD22 mAbs were generated that inhibit CD22 ligand binding to varying degrees. Remarkably, mAbs which blocked CD22 ligand binding accelerated mature B cell turnover by 2- to 4-fold in blood, spleen,...
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