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Article

A transcription factor PU.1 is critical for Ccl22 gene expression in dendritic cells and macrophages

4 Feb 2019

Abstract excerpt

The chemokine CCL22 is predominantly produced by dendritic cells (DCs) and macrophages. CCL22 acts on CCR4-expressing cells including Th2 and Treg. Although a correlation between the CCL22-CCR4 axis and allergic diseases has been established, the mechanism of monocyte lineage-specific Ccl22 gene expression is largely unknown. In the current study, we investigated transcriptional regulation of the Ccl22 gene in...

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PMID: 30718772
DOI: 10.1038/s41598-018-37894-9

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