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Article

Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia

15 May 2002

Abstract excerpt

Members of the Notch family encode transmembrane receptors that modulate differentiation, proliferation, and apoptotic programs of many precursor cells, including hematopoietic progenitors. Stimulation of Notch causes cleavage followed by translocation of the intracellular domain (NotchIC) to the nucleus, where it activates transcription of CBF1 responsive genes. The aim of this study was to elucidate the...

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PMID: 11986231
DOI: 10.1182/blood.v99.10.3742

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Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemiaPMID 11986231Read ↗

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