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Article

Identification of a gene on chromosome 12q22 uniquely overexpressed in chronic lymphocytic leukemia.

Blood - 1 Apr 2006

Buhl Anne Mette, Jurlander Jesper, Jørgensen Flemming S, Ottesen Anne Marie, Cowland Jack B, Gjerdrum Lise Mette, Hansen Brian V, Leffers Henrik

Abstract excerpt

The pathogenesis of chronic lymphocytic leukemia (CLL) is unknown but may involve aberrant activation of signaling pathways. Somatic hypermutations in rearranged immunoglobulin heavy-chain (IgVH) genes allow a division of CLL patients into 2 categories: mutated IgVH genes are associated with an i...

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Share to Chromosome Mapping
Share to Chromosomes, Human, Pair 12
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Neoplasm Proteins

Share to RNA, Long Noncoding

Source

Identifiers

PMID: 16339396
DOI: 10.1182/blood-2005-07-2615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16339396-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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