Article
CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1.
The Journal of biological chemistry - 23 Nov 2001
Otipoby K L, Draves K E, Clark E A
Abstract excerpt
Recognition of antigen by the B cell antigen receptor (BCR) determines the subsequent fate of a B cell and is regulated in part by the involvement of other surface molecules, termed coreceptors. CD22 is a B cell-restricted coreceptor that gets rapidly tyrosyl-phosphorylated and recruits various signaling molecules to the membrane following BCR ligation. Although CD22 contains three immunoreceptor tyrosine-based...
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