B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines.

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Article

B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1997

Nadler M J, McLean P A, Neel B G, Wortis H H

Abstract excerpt

CD22 is a B cell membrane glycoprotein that, upon Ag receptor engagement, becomes rapidly tyrosyl phosphorylated and associates with several signaling molecules including Lyn, Syk, PLCgamma1, and the protein-tyrosine phosphatase, SHP-1. Two allelic forms of murine CD22 exist: CD22.1 is expressed...

Topics

Alleles
Animals
Antigens, CD
Antigens, Differentiation, B-Lymphocyte
B-Lymphocytes
Calcium
Cell Adhesion Molecules
Cell Line
Gene Deletion
Ion Transport
Lectins
Mice
Receptors, Antigen, B-Cell
Sialic Acid Binding Ig-like Lectin 2
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 9379018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9379018-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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