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Article

A novel hypergraph model for identifying and prioritizing personalized drivers in cancer.

PLoS computational biology - 1 Apr 2024

Zhang Naiqian, Ma Fubin, Guo Dong, Pang Yuxuan, Wang Chenye, Zhang Yusen, Zheng Xiaoqi, Wang Mingyi

Abstract excerpt

Cancer development is driven by an accumulation of a small number of driver genetic mutations that confer the selective growth advantage to the cell, while most passenger mutations do not contribute to tumor progression. The identification of these driver genes responsible for tumorigenesis is a crucial step in designing effective cancer treatments. Although many computational methods have been developed with...

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Identifiers

PMID: 38683860
DOI: 10.1371/journal.pcbi.1012068
PMCID: PMC11081510

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LRP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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