Article

Widespread alteration of protein autoinhibition in human cancers

2018-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Autoinhibition is a prevalent allosteric regulatory mechanism in signaling proteins as it prevents spurious pathway activation and primes for signal propagation only under appropriate inputs. Altered functioning of inhibitory allosteric switches underlies the tumorigenic potential of numerous cancer drivers. However, whether protein autoinhibition is altered generically in cancer cells remains e...

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Literature Corpus work: 70a78bfa-13db-5cef-a38e-acfec7d947f4
DOI: 10.1101/450296

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