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Article

Taming Oncogenic Signaling at Protein Interfaces: Challenges and Opportunities.

Current topics in medicinal chemistry - 1 Jan 2015

Cavga Ayse Derya, Karahan Nilay, Keskin Ozlem, Gursoy Attila

Abstract excerpt

Many key cellular events determining the thin line between healthy and oncogenic behavior rely on the proper functioning of protein-protein interactions (PPIs). Alterations that affect the affinity of a protein-protein binding site may destabilize a desired healthy interaction, or stabilize an oncogenic interaction. The understanding that there are a few key hot-spot residues that are mainly responsible for the...

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Identifiers

PMID: 25986691
DOI: 10.2174/1568026615666150519101956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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