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Article

Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants.

Cell reports - 18 Oct 2016

Brenan Lisa, Andreev Aleksandr, Cohen Ofir, Pantel Sasha, Kamburov Atanas, Cacchiarelli Davide, Persky Nicole S, Zhu Cong, Bagul Mukta, Goetz Eva M, Burgin Alex B, Garraway Levi A, Getz Gad, Mikkelsen Tarjei S, Piccioni Federica, Root David E, Johannessen Cory M

Abstract excerpt

Tumor-specific genomic information has the potential to guide therapeutic strategies and revolutionize patient treatment. Currently, this approach is limited by an abundance of disease-associated mutants whose biological functions and impacts on therapeutic response are uncharacterized. To begin to address this limitation, we functionally characterized nearly all (99.84%) missense mutants of MAPK1/ERK2, an...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase 1

Share to Models, Molecular

Share to Mutation, Missense

Share to Phosphorylation

Share to Protein Kinase Inhibitors

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Source

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Identifiers

PMID: 27760319
DOI: 10.1016/j.celrep.2016.09.061
PMCID: PMC5120861

Genes

MAPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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