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Article

ERK2 Mutations Affect Interactions, Localization, and Dimerization.

Biochemistry - 2 May 2023

Taylor Clinton A, Cormier Kevin W, Martin-Vega Ana, Earnest Svetlana, Stippec Steve, Wichaidit Chonlarat, Cobb Melanie H

Abstract excerpt

The most frequent ERK2 (MAPK1) mutation in cancers, E322K, lies in the common docking (CD) site, which binds short motifs made up of basic and hydrophobic residues present in the activators MEK1 (MAP2K1) and MEK2 (MAP2K2), in dual specificity phosphatases (DUSPs) that inactivate the kinases, and in many of their substrates. Also, part of the CD site, but mutated less often in cancers, is the preceding aspartate...

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PMID: 37021821
DOI: 10.1021/acs.biochem.3c00044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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