Article

Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors

2021-08-20

Abstract excerpt

<h4>ABSTRACT</h4> Essential functions of mitogen-activated protein kinases (MAPKs) depend on their capacity to selectively phosphorylate a limited repertoire of substrates. MAPKs harbor a conserved groove located outside of the catalytic cleft that binds to short linear sequence motifs found in substrates and regulators. However, the weak and transient nature of these “docking” interactions poses a challenge to d...

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Literature Corpus work: 386fb8a7-d4ba-5942-a024-311e413c61ae
DOI: 10.1101/2021.08.20.457142

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