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Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors

10 Jan 2023

Abstract excerpt

Essential functions of mitogen-activated protein kinases (MAPKs) depend on their capacity to selectively phosphorylate a limited repertoire of substrates. MAPKs harbor a conserved groove located outside of the catalytic cleft that binds to short linear sequence motifs found in substrates and regulators. However, the weak and transient nature of these "docking" interactions poses a challenge to defining MAPK...

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PMID: 36626580
DOI: 10.1126/scisignal.abm5518

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