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Article

The Landscape of Atypical and Eukaryotic Protein Kinases.

Trends in pharmacological sciences - 1 Nov 2019

Kanev Georgi K, de Graaf Chris, de Esch Iwan J P, Leurs Rob, Würdinger Thomas, Westerman Bart A, Kooistra Albert J

Abstract excerpt

Kinases are attractive anticancer targets due to their central role in the growth, survival, and therapy resistance of tumor cells. This review explores the two primary kinase classes, the eukaryotic protein kinases (ePKs) and the atypical protein kinases (aPKs), and provides a structure-centered comparison of their sequences, structures, hydrophobic spines, mutation and SNP hotspots, and inhibitor interaction...

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Source

Identifiers

PMID: 31677919
DOI: 10.1016/j.tips.2019.09.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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