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Article

Astrocyte-Specific Phenotyping of FAD4T as an Alzheimer's Disease Mouse Model.

Glia - 1 Jun 2025

Kim Ki Jung, Lee Jae-Hun, Lim Jiwoon, Lee Taehee, Joo Jinhyeong, Bhalla Mridula, Wang Tao, Feng Rui, Lee C Justin

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, characterized by memory decline and behavioral changes. Its pathological features include senile plaques, neurofibrillary tangles, and reactive gliosis, comprising abnormal accumulations of β-amyloid peptide (Aβ) and hyperphosphorylated tau protein surrounded by reactive astrocytes and microglia. Recently, it has emerged that severe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40009021
DOI: 10.1002/glia.70002

Genes

MAOB
CA1
GFAP
LCN2

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