Article

Integrated Cross-Disease Atlas of Human And Mouse Astrocytes Reveals Heterogeneity and Conservation of Astrocyte Subtypes in Neurodegeneration

2025-02-14

Abstract excerpt

Astrocytes play a pivotal role in central nervous system homeostasis and neuroinflammation. Despite advancements in single-cell analyses, the heterogeneity of reactive astrocytes in neurodegenerative diseases, particularly across species, remains understudied. Here, we present an integrated atlas of 187,000 astrocytes from mouse models of Alzheimer’s (AD) and multiple sclerosis (MS) alongside 438,000 astrocytes fr...

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Literature Corpus work: 4d3b3876-c890-5994-9125-4e545dfffaa6
DOI: 10.1101/2025.02.12.637903

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