Article

Tβ4 and PDTC displayed recovery on the glial and neuronal alterations in an early Alzheimer’s disease model

2022-06-13

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) is the leading cause of dementia, with no effective therapies to reduce this progressive form of nerve cell death. Peptide thymosin β4 (Tβ4) controls actin polymerization and showed reduced neuroinflammation in middle stage AD model mice. To report the effect and mechanism of Tβ4 in early stage of AD model mice, Tβ4 overexpression or knockdown in 4 months APP/PS...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 58094a27-746f-5b16-a913-05c1371033e1
DOI: 10.21203/rs.3.rs-1691973/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tβ4 and PDTC displayed recovery on the glial and neuronal alterations in an early Alzheimer’s disease modelDOI 10.21203/rs.3.rs-1691973/v1Read

Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.Semantic proximity Read

Tetramethylpyrazine Nitrone (TBN) Reduces Amyloid β Deposition in Alzheimer's Disease Models by Modulating APP Expression, BACE1 Activity, and Autophagy PathwaysSemantic proximity Read

Astrocyte-Specific Phenotyping of FAD4T as an Alzheimer's Disease Mouse Model.Semantic proximity Read

Effects of TYROBP Deficiency on Neuroinflammation of a Alzheimer's Disease Mouse Model Carrying a PSEN1 p.G378E Mutation.Semantic proximity Read

Nanotechnology Therapy for Alzheimer's Disease Memory Impairment Attenuation.Semantic proximity Read

A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer’s mouse modelSemantic proximity Read

Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoidsSemantic proximity Read

[Current status of Alzheimer's disease immunotherapy and pharmacologic effect of BAN2401.].Semantic proximity Read

K284-6111 Alleviates Memory Impairment and Neuroinflammation in Tg2576 Mice by Inhibition of Chitinase-3-like 1 Regulating ERK Dependent PTX3 PathwaySemantic proximity Read

Next-generation neurotherapeutics: nanotechnology, immunotherapy, and gene editing for neurodegenerative diseasesSemantic proximity Read

The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer’s DiseaseSemantic proximity Read

Prevention of Amyloid-β and Tau Pathologies, Associated Neurodegeneration, and Cognitive Deficit by Early Treatment with a Neurotrophic Compound.Semantic proximity Read