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Article

GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis

1 Dec 2018

Abstract excerpt

GJA1 (connexin43) has been predicted as the top key driver of an astrocyte enriched subnetwork associated with Alzheimer's disease (AD). In this study, we comprehensively examined GJA1 expression across 29 transcriptomic and proteomic datasets from post-mortem AD and normal control brains. We demonstrated that GJA1 was strongly associated with AD amyloid and tau pathologies and cognitive functions. RNA sequencing...

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PMID: 30577786
DOI: 10.1186/s40478-018-0642-x

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