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Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease

23 Jul 2024

Abstract excerpt

BACKGROUND: Astrocytes, one of the most resilient cells in the brain, transform into reactive astrocytes in response to toxic proteins such as amyloid beta (Aβ) in Alzheimer's disease (AD). However, reactive astrocyte-mediated non-cell autonomous neuropathological mechanism is not fully understood yet. We aimed our study to find out whether Aβ-induced proteotoxic stress affects the expression of autophagy genes...

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PMID: 39044253
DOI: 10.1186/s13024-024-00740-w

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