Article

Integrated Cross-Disease Atlas of Human And Mouse Astrocytes Reveals Heterogeneity and Conservation of Astrocyte Subtypes in Neurodegeneration

2025-03-25

Abstract excerpt

<title>Abstract</title> <p>Astrocytes play a pivotal role in central nervous system homeostasis and neuroinflammation. Despite advancements in single-cell analyses, the heterogeneity of reactive astrocytes in neurodegenerative diseases, particularly across species, remains understudied. Here, we present an integrated atlas of 187,000 astrocytes from mouse models of Alzheimer's (AD) and multiple sclerosis (MS) alo...

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Literature Corpus work: 1398046f-cc3b-5dea-baf0-07a454896db1
DOI: 10.21203/rs.3.rs-5990285/v1

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