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Epistasis and cryptic QTL identified using modified bulk segregant analysis of copper resistance in budding yeast.

Genetics - 17 Apr 2025

Buzby Cassandra, Plavskin Yevgeniy, Sartori Federica M O, Tong Qiange, Vail Janessa K, Siegal Mark L

Abstract excerpt

The contributions of genetic interactions to natural trait variation are challenging to estimate experimentally, as current approaches for detecting epistasis are often underpowered. Powerful mapping approaches such as bulk segregant analysis (BSA), wherein individuals with extreme phenotypes are pooled for genotyping, obscure epistasis by averaging over genotype combinations. To accurately characterize and...

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Identifiers

PMID: 39989051
DOI: 10.1093/genetics/iyaf026
PMCID: PMC12005261

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