Article
Dissection of genetically complex traits with extremely large pools of yeast segregants.
Nature - 15 Apr 2010
Ehrenreich Ian M, Torabi Noorossadat, Jia Yue, Kent Jonathan, Martis Stephen, Shapiro Joshua A, Gresham David, Caudy Amy A, Kruglyak Leonid
Abstract excerpt
Most heritable traits, including many human diseases, are caused by multiple loci. Studies in both humans and model organisms, such as yeast, have failed to detect a large fraction of the loci that underlie such complex traits. A lack of statistical power to identify multiple loci with small effects is undoubtedly one of the primary reasons for this problem. We have developed a method in yeast that allows the use...
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